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However, UK is concerned about the virus, and the government is taking several measures to prevent the virus from getting out of control, according to The Department of Health for this purpose, a total of 6,536 tests relating to coronavirus have been conducted, in which 6,527 tests resulted as negative.

Coronavirus in The West
Moreover, in Europe, most cases regarding the coronavirus have been reported in Italy, the individual that came positive is almost 165, and has taken five lives up till now, however, Italy to has taken several measures to prevent an outbreak of the virus. However, still, it has led to five deaths, and it is also on the rise in several small towns that are in the Veneto and Lombardy region.

It can be argued that the UK has to take more advanced measure to prevent the spread of the virus, taking Italy as an example as they tried their best to prevent it but still was unsuccessful in controlling it. UK’s prime minister’s office said that they would consult with the public health and medical experts taking all the necessary steps which that are best to protect the British citizens.

However, according to the statistics, the risk to individuals to get affected remains typically low as 99% of the individual’s that have been tested in the UK is found to be negative. The Prime Minister’s Spokesperson further assessed that they are well prepared for the UK cases, and said that they are using recommended procedures to prevent the spread of the Virus and NHS as well-equipped in managing infections.

NHS took measures
Some of the necessary actions taken by NHS are;

The NHS putting professional teams in every ambulance service and also some hospital units
Coronavirus diagnostic tests getting rolled out to labs across the UK, to enable greater than 1,000 folks one day to be tested
The Foreign Office carrying out “enhanced monitoring” of direct flights from 9 countries: China, Singapore, Taiwan, Hong Kong, South Korea, Japan, Thailand, Macau and Malaysia
New legal powers being given to enable the authorities to maintain people suspected of keeping the disease in isolation
Moreover, The Foreign Office updated its travel information for Italy over the weekend, the spokesman added. Ireland’s Department of Foreign Affairs has encouraged the citizens of its to not take a trip to affected areas of Italy. Meanwhile, rugby matches in Italy affecting Welsh club Ospreys and also Irish side Ulster are delayed because of limitations enforced by officials dealing with the outbreak in Italy.

Plans are now being made to reschedule each fixture, which was due to occur on Saturday. The UK has provided equipment such as facemasks to China to help fight the spread of the illness, the spokesman confirmed. “We have supplied (the Chinese government) with 1,800 goggles, 37,500 medical gowns, 194,000 sanitizing wipes, 430,000 disposable gloves & 2,500 facemasks,” he said.

Coronavirus Statistics
Moreover, the entire number of UK cases has risen to thirteen after four cruise ship passengers flown to Britain on Saturday tested positive for the disease. They were among thirty repatriated Britons along with 2 Irish people starting up 14-day quarantine at Arrow Park Hospital in Wirral.

The 4 UK nationals caught the disease on the Diamond Princess liner in Japan and are receiving treatment in specialist NHS infection centres. Separately, 4 Britons from the ship that just recently tested positive for the brand-new coronavirus weren’t on Saturday’s repatriation flight.

They included David and Sally Abel, from Northampton shire, which I’ve since been identified as having pneumonia, based on the loved ones of theirs and are receiving treatment in a Japanese medical Centre.

Elsewhere, countries such as South Korea, Iran and Italy are fighting to contain the disease, which causes respiratory illness Covid-19. About 77,000 individuals in China, in which the disease emerged last season, are taken over as well as nearly 2,600 have died. Over 1,200 cases have been established in approximately thirty other places, and there have been over twenty deaths.

Essential Aspects to Consider About Coronavirus
Symptoms: The primary symptoms of the disease are fever (high temperature) along with a cough in addition to shortness of breathing and breathing problems.

Prevention: Frequent hand washing with gel or maybe soap, staying away from close contact with individuals who are ill and never touching your mouth, nose, and eyes with unwashed hands can help cut the danger of infection.

Catching sneezes and coughs in a tissue, binning it and washing the hands of yours can minimize the danger of spreading illness.

Anyone having symptoms, even if gentle, after travelling from mainland China, Thailand, Japan, Republic of Korea, Hong Kong, Taiwan, Singapore, Macau or Malaysia, is encouraged to remain inside and also phone the NHS 111 telephone service.

Role of the UK Government
The primary focus is on quickly identifying individuals with the illness and also bringing them to specialized hospitals for treatment in isolation.

They’re then tracing anyone that has come into good communication with the patient to ensure they understand the signs of the illness and how to proceed.

Narsoplimab
Narsoplimab is a fully human IgG4 monoclonal antibody that targets mannose-binding lectin-associated serine protease 2 (MASP-2) and was developed to treat thrombotic microangiopathy (HSCT-TMA) related to hematopoietic stem cell transplantation. MASP-2 is an effector enzyme of the lectin pathway of the complement system. The lectin pathway is activated primarily by tissue damage or microbial infection. Importantly, unlike other complement-targeted drugs on the market or under development, the inhibitory effect of narsoplimab on MASP-2 does not interfere with the classical complement pathway, which is a key component of the immune response to acquired infections. The role of narsoplimab is to prevent complement-mediated inflammation and endothelial damage without affecting the function of other innate immune pathways.

Developed by Omeros, narsoplimab has been granted breakthrough drug status in the United States for the treatment of high-risk HSCT-TMA patients. Currently, narsoplimab is also in phase III clinical development and is being developed for the treatment of IgA nephropathy (IgAN) and atypical hemolytic uremic syndrome (aHUS). Previously, it was also granted orphan drugs and breakthrough drugs for IgAN in the United States, fast-track qualification for aHUS, and orphan drugs for IgAN in the European Union.

REGN-EB3
REGN-EB3 is a mixture of three fully human IgG1 mAbs, and is used for the treatment of Ebola virus infection. Ebola virus is the culprit causing Ebola hemorrhagic fever (EHF), an acute viral infectious disease with symptoms including fever, headache, joint and muscle pain, fatigue, diarrhea, vomiting, stomach pain, loss of appetite and abnormal bleeding. In the United States and the European Union, REGN-EB3 has been granted orphan drug status and has been awarded Breakthrough Drug Status (BTD) in the United States. In addition to REGN-EB3, a therapeutic mAb -mAb114- has also been awarded orphan drug status and BTD.

Isatuximab
Isatuximab is an anti-CD38 IgG1 chimeric monoclonal antibody developed for the treatment of multiple myeloma (MM). The drug targets specific epitopes of CD38 receptors in plasma cells and can trigger a variety of unique mechanisms of action, including promoting programmed tumor cell death (apoptosis) and immunomodulatory activity. CD38 is expressed at high levels on MM cells and is a target for cell surface receptors for antibody therapy in MM and other malignancies.

Isatuximab was developed by Sanofi, and its applications for marketing for relapsed or refractory MM are under review by the US FDA and EU EMA. In the United States and the European Union, the drug is licensed as an orphan drug for relapsed or refractory MM. In a pivotal phase III ICARIA-MM study, isatuximab combined with pom-dex (pomalidomide + dexamethasone) significantly reduced the risk of disease progression or death by 40% and improved overall response compared to standard care. Currently, Sanofi is also evaluating the potential of isatuximab to treat other hematological malignancies and solid tumors.

Sacituzumab govitecan
Sacituzumab govitecan is a novel, first-in-class antibody drug conjugate (ADC) that combines the humanized IgG1 antibody targeting the TROP-2 antigen with SN-38, the metabolic activity of the chemotherapeutic drug irinotecan (a topoisomerase I inhibitor). It is currently being developed for the treatment of metastatic triple negative breast cancer (mTNBC). TNBC is a type of breast cancer with very limited treatment options. TROP-2 is a cell surface glycoprotein that is expressed in more than 90% of TNBC.

Developed by Immunomedics, Sacituzumab govitecan was submitted to the FDA in May 2018 for accelerated approval for mTNBC patients who have previously received at least 2 therapies for metastatic disease. However, it was rejected by the FDA in January 2019 because of manufacturing-related issues and no new clinical or preclinical data was required. At the beginning of December 2019, the company re-submitted BLA to the FDA. The last updated Phase II clinical data of the month showed that the total response rate of mTNBC treated by the drug was 34% and the median response duration was 9 months. Currently, the company is conducting a confirmatory phase III study. If approved, the drug will be the first ADC to treat mTNBC.

Tafasitamab
Tafasitamab is a novel humanized Fc domain-targeted CD19-optimized immune-enhancing IgG1 monoclonal antibody developed for the treatment of two types of B-cell malignancies: diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). CD19 is a clear biomarker for a variety of B-cell malignancies. The drug’s Fc domain has been optimized to improve its affinity for activated FcγRIIIa on effector cells, significantly enhance antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell phagocytosis (ADCP), thereby improving the key mechanism of tumor cell killing. In preclinical model studies, tafasitamab has been shown to induce direct apoptosis of cancer cells by binding to CD19.

The drug was developed by MorphoSys. At the end of last month, the company announced that it had completed its BLA submission and approved the application of tafasitamab in combination with lenalidomide in the treatment of patients with relapsed or refractory DLBCL. In the United States and the European Union, the drug has been granted orphan drug status for the treatment of DLBCL, and in the United States has also been granted fast-track status and breakthrough drug status for DLBCL. In a phase III clinical study, the total response rate of the drug combined with lenalidomide reached 60%, the complete response rate reached 43%, and the median progression-free survival was 12.1 months. Remissions are persistent with a median duration of 21.7 months. If approved, the drug will pose serious challenges to two CAR-T cell therapies on the market for relapsed or refractory DLBCL, including Novartis’ Kymriah and Gilead’s Yescarta.